Chengxiang Qiu
Chengxiang (CX) Qiu, Ph.D.
Assistant Professor
Department of Molecular and Systems Biology
Dartmouth College
E-mail: Chengxiang.Qiu@dartmouth.edu
Research Interests
Chengxiang (CX) Qiu is a computational biologist specializing in single-cell transcriptomics and developmental biology. Building on his expertise in single-cell genomics, human disease genetics, and mammalian development, Chengxiang’s lab aims to investigate how cell differentiation and lineage commitment are orchestrated through the regulation of gene expression, with the goal of uncovering the molecular and cellular mechanisms underlying both normal human development and developmental disorders, particularly neurodevelopmental disorders.
Selected Publication
Qiu C*#, Martin BK*, Welsh IC*, Daza RM, Le TM, Huang X, Nichols EK, Taylor ML, Fulton O, O’Day DR, Gomes AR, Ilcisin S, Srivatsan S, Deng X, Disteche CM, Noble WS, Hamazaki N, Moens CB, Kimelman D, Cao J, Schier AF, Spielmann M, Murray SA, Trapnell C, Shendure J#. A single-cell time-lapse of mouse prenatal development from gastrula to birth. Nature. 2024;626(8001):1084–93.
Regalado SG*, Qiu C*, Kottapalli S, Martin BK, Chen W, Liao H, Kim H, Li X, Lalanne J, Hamazaki N, Domcke S, Choi J#, Shendure J#. Lineage recording in monoclonal gastruloids reveals heritable modes of early development. bioRxiv. 2025.
Regalado SG*, Qiu C*, Lalanne J, Martin BK, Duran M, Trapnell C, Keith A, Domcke S, Shendure J. Barcoded monoclonal embryoids are a potential solution to confounding bottlenecks in mosaic organoid screens. bioRxiv. 2025.
Huang X*, Henck J*, Qiu C*, Sreenivasan VKA, Balachandran S, Amarie OV, Hrabě de Angelis M, Behncke RY, Chan WL, Despang A, Dickel DE, Haag N, Hägerling R, Hansmeier N, Hennig F, Marshall C, Rajderkar S, Ringel A, Robson M, Saunders L, SR, Ulferts S, Wittler L, Zhu Y, Kalscheuer VM, Ibrahim D, Kurth I, Kornak U, Beier DR, Visel A, Pennacchio LA, Trapnell C, Cao J#, Shendure J#, Spielmann M#. Single-cell, whole-embryo phenotyping of mammalian developmental disorders. Nature. 2023;623(7988):772–81.
Qiu C#, Cao J, Martin BK, Li T, Welsh IC, Srivatsan S, Huang X, Calderon D, Noble WS, Disteche CM, Murray SA, Spielmann M, Moens CB, Trapnell C, Shendure J#. Systematic reconstruction of cellular trajectories across mouse embryogenesis. Nat Genet. 2022;54(3):328–41.
Qiu C*, Huang S*, Park J, Park Y, Ko YA, Seasock MJ, Bryer JS, Xu XX, Song WC, Palmer M, Hill J, Guarnieri P, Hawkins J, Boustany-Kari CM, Pullen SS, Brown CD, Susztak K#. Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease. Nat Med. 2018;24(11):1721–31.
Qiu C, Hanson RL#, Fufaa G, Kobes S, Gluck C, Huang J, Chen Y, Raj D, Nelson RG, Knowler WC, Susztak K#. Cytosine methylation predicts renal function decline in American Indians. Kidney Int. 2018;93(6):1417–31.